Thermo Fisher Scientific Phospho-ALK (Tyr1507) Polyclonal Antibody
Phospho-ALK (Tyr1507) 폴리클로날 항체로 ALK 단백질의 Tyr1507 인산화 부위를 특이적으로 인식합니다. Western blot 및 IHC(파라핀) 응용에 적합하며, 고순도 Rabbit IgG 포맷으로 제공됩니다. 뇌 발달 및 종양 연구용으로 최적화된 연구용 시약입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ALK around the phosphorylation site of Tyr1507 (P-T-YP-G-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554955 |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement commonly creates a fusion gene consisting of ALK and nucleophosmin (NPM).
The NPM-ALK fusion gene product is oncogenic. ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, which are absent in the NPM-ALK product. ALK shows high sequence similarity to LTK and plays an important role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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