Thermo Fisher Scientific ACER3 Polyclonal Antibody
ACER3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 유세포분석(Flow cytometry)에 사용 가능. Human 및 Mouse 시료에 반응하며, Protein A 및 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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- PA549661
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 224–250 of the C-terminal region of human ACER3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2635114 |
Target Information
ACER3 is a protein-coding gene encoding an endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain ceramides, dihydroceramides, and phytoceramides into sphingoid bases such as sphingosine and free fatty acids at alkaline pH.
Ceramides, sphingosine, and sphingosine-1-phosphate are bioactive lipids involved in cellular signaling pathways that regulate proliferation, apoptosis, and differentiation.
ACER3 controls sphingosine generation in erythrocytes and consequently sphingosine-1-phosphate levels in plasma. It may also play a role in neuronal survival and function by maintaining lipid homeostasis in the brain and modulating inflammatory responses through regulation of ceramide levels in immune cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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