Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Synaptotagmin 1 단백질을 표적하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. WB 및 IHC(P) 응용에 적합하며, 신경전달물질 방출과 시냅스 소포 조절 연구에 활용. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 10–60 of rat Synaptotagmin 1) conjugated to carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Antigen is homologous in mouse.
- Specificity: Synaptotagmin 1.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS. It acts as a Ca²⁺ sensor in the regulation of exocytosis and neurotransmitter release. Ca²⁺-mediated binding of Synaptotagmin 1 to SNAP25 is essential for triggering membrane fusion. Specific residues within its C2B domain regulate endocytic rate and vesicle size. Synaptotagmin 1 interacts with acidic phospholipids and several proteins including neurexins, syntaxin, and AP2. Dysfunction is associated with food-borne and infant botulism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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