Thermo Fisher Scientific PrP Polyclonal Antibody

Applications

• Immunohistochemistry (Frozen) (IHC (F))
  Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Reconstitute with 50–100 µL of distilled water, and dilute further in 0.1 M PBS containing 1% BSA and 0.1% sodium azide.

Target Information

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with the pathogenesis of prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD).
While PrPc is rich in alpha-helices, the PrPSc form has higher beta-sheet content and is resistant to proteinase K.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.