Thermo Fisher Scientific PrP Polyclonal Antibody
Rabbit polyclonal antibody against rat PrP for immunohistochemistry (frozen). Lyophilized form, unconjugated, stored at 4°C. Suitable for research use in prion protein studies and neurodegenerative disease mechanisms.
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Applications
- Immunohistochemistry (Frozen) (IHC (F))
Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic rat PRP conjugated to BSA. Tested on rat tissues. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_2172282 |
Product Specific Information
Reconstitute with 50–100 µL of distilled water, and dilute further in 0.1 M PBS containing 1% BSA and 0.1% sodium azide.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with the pathogenesis of prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD).
While PrPc is rich in alpha-helices, the PrPSc form has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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