Thermo Fisher Scientific FXIIIA Polyclonal Antibody, Biotin
Human FXIIIA 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체. Western blot, IHC, ICC, ELISA, IP 등 다양한 응용 가능. 합성 펩타이드 항원으로 제작되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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- FXIIIA121BIOTIN
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Multi-epitope synthetic peptides corresponding to amino acid ranges 1–50 and 700–732 of Factor XIII A. A mixture of synthetic peptides used for FXIIIA-101AP and FXIIIA-112AP. |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol and 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the coagulation factor XIII A subunit, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer of two A subunits (catalytic) and two B subunits (carrier). Platelet factor XIII contains only A subunits. Upon thrombin activation in the presence of calcium ions, the B subunits dissociate, forming the active enzyme factor XIIIa. This enzyme functions as a transglutaminase, catalyzing crosslinking between fibrin molecules to stabilize the clot. It also crosslinks α2-plasmin inhibitor or fibronectin to fibrin α chains. Factor XIII deficiency can be type I (absence of both A and B subunits) or type II (absence of A subunit only), leading to bleeding disorders, poor wound healing, and recurrent miscarriage.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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