Thermo Fisher Scientific DKC1 Polyclonal Antibody
DKC1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 생쥐, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 용액 형태로 -20°C에 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human Dyskerin (amino acids 195–218) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635223 |
Product Specific Information
This antibody detects endogenous levels of total DKC1 protein.
Target Information
This gene is a member of the H/ACA snoRNPs gene family, which is involved in various aspects of rRNA processing and modification. The protein encoded by this gene, along with NOLA1, NOLA2, and NOLA3, localizes to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Depletion of any of these four proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex. The encoded protein is related to Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. Mutations in this gene cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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