Thermo Fisher Scientific PPP3CC Polyclonal Antibody

Thermo Fisher Scientific PPP3CC Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000–1:10,000
Publications: -

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32
• Predicted reactivity: Mouse (93%), Rat (93%), Bovine (97%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum.

The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least three genes—calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3)—have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90–95% amino acid identity).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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