Thermo Fisher Scientific ADAR1 Polyclonal Antibody
ADAR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 인간 반응성, 항원 친화 크로마토그래피로 정제. RNA 편집 연구 및 바이러스 관련 연구에 적합.
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Thermo Fisher Scientific ADAR1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 950 and 1000 of human Adenosine Deaminase, RNA-specific |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, predicted to react with Mouse and Rat
Target Information
Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (A-to-I RNA editing). This process can influence gene expression and function by altering mRNA translation, pre-mRNA splicing, RNA stability, and viral RNA replication.
ADAR1 edits both viral and cellular RNAs, including:
- Cellular substrates: BLCAP, GRIA2, HTR2C, GABRA3
- Viral substrates: HCV, VSV, MV, HDV, HIV-1
ADAR1 can have proviral or antiviral effects depending on the virus and editing mechanism. It plays roles in RNA virus replication, mRNA translation, and protein-RNA interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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