Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
IKK epsilon 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 및 마우스 시료에 반응합니다. Western blot과 ICC/IF에 적합하며, NF-κB 신호전달 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
- 카탈로그번호
- PA528264
- 판매단위
- pk
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Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 123–636 of Human IKBKE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545740 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat, Raji
- Predicted reactivity: Mouse (84%), Rat (85%), Bovine (88%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and its suppression induces cell death.
NF-κB is a transcription factor mediating gene expression during immune and inflammatory responses. It is associated with Ikappa-B proteins that inhibit its activity in the cytoplasm.
Ikappa-B phosphorylation occurs via the IKK complex (IKK-α, IKK-β, IKK-γ). A novel molecule, IKK-iota/IKK-i (IKK epsilon), is required for NF-κB activation by PMA and T cell receptors, but not by TNF-α or IL-1.
IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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