Thermo Fisher Scientific IKK epsilon Polyclonal Antibody

Thermo Fisher Scientific IKK epsilon Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Predicted reactivity: Mouse (84%), Rat (85%), Bovine (88%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and its suppression induces cell death.
NF-κB is a transcription factor mediating gene expression during immune and inflammatory responses. It is associated with Ikappa-B proteins that inhibit its activity in the cytoplasm.
Ikappa-B phosphorylation occurs via the IKK complex (IKK-α, IKK-β, IKK-γ). A novel molecule, IKK-iota/IKK-i (IKK epsilon), is required for NF-κB activation by PMA and T cell receptors, but not by TNF-α or IL-1.
IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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