Thermo Fisher Scientific Phospho-Zap-70 (Tyr493) Recombinant Rabbit Monoclonal Antibody (7L3Y5)
ZAP-70 단백질의 Tyr493 인산화를 인식하는 재조합 토끼 단클론 항체. ICC/IF 및 ELISA에 적합. 높은 특이성과 재현성을 제공하며, T세포 신호전달 연구에 유용. Protein A로 정제된 액상 형태로 -20°C에서 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7L3Y5 |
| Immunogen | A synthetic phosphorylated peptide around Y493 of human ZAP70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.41 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
- Immunogen Sequence: SYYTA
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that belongs to the Syk family of proteins. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor (TCR) activation. Upon TCR engagement, ZAP70 is phosphorylated at tyrosines 292, 315, and 319 in the interdomain B region, located between the SH2 and kinase domains. Phosphorylation of tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP70 function in lymphocyte signaling, while phosphorylation at tyrosine 292 terminates transient activation and attenuates signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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