Thermo Fisher Scientific PLCG2 Recombinant Rabbit Monoclonal Antibody (0M1U7)
PLCG2 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현된 재조합 항체이며, Protein A로 정제되었습니다. PBS 버퍼에 보관되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 0M1U7 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 701–800 of PLC gamma 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.84 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
HFVLGTSAYF ESLVELVSYY EKHSLYRKMR LRYPVTPELL ERYNMERDIN SLYDVSRMYV DPSEINPSMP QRTVKALYDY KAKRSDELSF CRGALIHNVS
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers—inositol 1,4,5-triphosphate and diacylglycerol—from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta2, and PLCe.
PLC delta1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It also functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling.
Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLC delta has been observed in brains of Alzheimer’s disease patients, suggesting a potential role in disease pathology.
PLC delta2 is expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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