Thermo Fisher Scientific IL18BP Polyclonal Antibody
IL18BP 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. Protein A 정제, 1 mg/mL 액상 형태로 제공되며 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human IL18BP (amino acids 91–194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity.
As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to diseases such as eczema, asthma, and Crohn’s disease. Upregulation of IL-18BP by keratinocytes expressing the HPV E7 oncoprotein decreases IL-18-induced IFN-gamma production and T cell activation. Elevated IL-18 and IL-18BP levels, along with proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-1beta, IL-8), are associated with chronic inflammation and observed in macrophages and intestinal tissues of Crohn’s disease patients.
IL-18BP belongs to the immunoglobulin-like receptor class and contains a single Ig domain; two of the four identified human isoforms (b and d) have incomplete domains with reduced binding affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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