Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. Protein A로 정제된 액상 항체로 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SLC25A13, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675-amino-acid multi-pass mitochondrial inner membrane protein. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier, contributing to the urea cycle. It belongs to the mitochondrial carrier family and contains three Solcar repeats and four EF-hand domains for calcium binding.
Defects in the SLC25A13 gene cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
- CTLN2: Autosomal recessive urea cycle disorder characterized by neuropsychiatric symptoms (e.g., memory loss, seizures, coma).
- NICCD: Non-lethal infant disorder with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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