Thermo Fisher Scientific Phospho-PKR (Thr446) Recombinant Rabbit Monoclonal Antibody (2F8)
Phospho-PKR (Thr446) 항체로 인간 PKR 단백질의 인산화형을 특이적으로 검출. Western blot, IHC, ICC 등 다양한 응용에 적합. 재조합 토끼 단클론 항체로 높은 특이성과 재현성 제공. 바이러스 감염 및 신경퇴행 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2F8 |
| Immunogen | A synthesized peptide derived from human Phospho-EIF2AK2 (T446) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898197 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense by direct activation through double-stranded RNA produced during viral infection. PKR is critical in interferon-induced antiviral responses, virus-induced apoptosis, and regulation of cell growth and differentiation.
PKR induces apoptosis via Fas upregulation and mediates the FADD/Caspase-8 signaling pathway. Upon viral infection, it acts as a dual-function protein, sequentially activating both survival and cell death pathways through kinase-independent and -dependent mechanisms. PKR also regulates NF-kappaB activation, p53, p38, and PDGF signaling pathways and has been implicated in tumor suppression and malignancy. Additionally, PKR is associated with several neurodegenerative diseases, including Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis (ALS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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