Thermo Fisher Scientific p38 MAPK Recombinant Rabbit Monoclonal Antibody (HL1006)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: References

Product Specifications

Product Specific Information

• Centrifuge briefly prior to opening.

Target Information

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals.
p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif.
There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors.
When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation.
Activated MAPK kinase-3/6 phosphorylate Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 파일명: MA5-38272_p38_MAPK_Q16539-1_Rabbit.svg, MA5-38272_p38_MAPK_Q16539-1_Rabbit_PDP.jpeg)