Thermo Fisher Scientific KIFC2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100

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Immunohistochemistry (IHC)

-

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Immunoprecipitation (IP)

-

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Product Specifications

Published species

Mouse, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide: C S(780) G L T L E P P G D P P P(792) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KIFC2,uniProtId:O08672-1,ncbiNodeId:10090,antigenRange:780-792,antigenLength:792,antigenImageFileName:PA1-641_KIFC2_O08672-1_Rabbit.svg,antigenImageFileNamePDP:PA1-641_KIFC2_O08672-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2132542

Product Specific Information

PA1-641 detects kinesin C2 (KIFC2) from mouse tissues.

PA1-641 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~100 kDa protein representing KIFC2 from mouse brain homogenate.

PA1-641 immunizing peptide corresponds to amino acid residues 780-792 from mouse KIFC2. PA1-641 immunizing peptide (Cat. # PEP-041) is available for use in neutralization and control experiments.

Target Information

Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure which includes a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. An expansive phylogenetic tree of kinesins and kinesin-related proteins (KRPs) has been assembled based on this information. Kinesin C2 (KIFC2) is a C-type kinesin based on the position of the motor domain towards the carboxyl-terminus of the protein and is similar to members of the karyogamy protein 3 (KAR3) family involved in cell division. KIFC2 protein expression has been demonstrated in axons and dendrites of the central and peripheral nervous system. Unlike other C-type motor proteins, KIFC2 appears to play a role in retrograde axonal transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.