Thermo Fisher Scientific Paxillin Chimeric Recombinant Rabbit Monoclonal Antibody (LD2 sAB)
Paxillin LD2 모티프에 특이적으로 결합하는 재조합 토끼 단일클론 항체로 높은 특이성과 친화도를 가짐. Western blot 및 ELISA 등 다양한 면역분석에 사용 가능. HEK293 발현 시스템에서 생산된 IgG 형태의 액상 항체. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific Paxillin Chimeric Recombinant Rabbit Monoclonal Antibody (LD2 sAB)
Applications
- Western Blot (WB): Assay-dependent
- ELISA: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | LD2 sAB |
| Immunogen | Peptide corresponding to paxillin-LD2 motif (residues 141–156) fused to MBP; peptide sequence: NLSELDRLLLELNAVQHNP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074388 |
Product Specific Information
- Specificity: The antibody binds specifically to the LD-2 motif of human paxillin with a Kd of 24 nM.
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, independent of the extracellular matrix. Although initially discovered in fibroblasts, paxillin phosphorylation may also be important during neurite extension and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: MA5-47944_Paxillin_P49023-1_Rabbit_PDP.jpeg)
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