Thermo Fisher Scientific Nod2 Monoclonal Antibody (26mNOD2), eBioscience
마우스 NOD2 단백질을 인식하는 단클론 항체로, Western blotting에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며, PBS(pH 7.2)에 0.09% sodium azide가 포함되어 있습니다. 4°C에서 보관하며, Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Nod2 Monoclonal Antibody (26mNOD2), eBioscience
Applications and Publications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 5 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 26mNOD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1107023 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
The monoclonal antibody 26mNOD2 reacts with mouse NOD2.
NOD2, also known as caspase recruitment domain-containing protein 15 (CARD15), is a cytosolic protein (~115 kDa) containing:
- A central NOD (nucleotide oligomerization domain)
- A C-terminal leucine-rich repeat (LRR) domain
- An N-terminal CARD domain
The LRR domain recognizes microbial components such as muramyl dipeptide, while the CARD domain interacts with RIP2 via homotypic CARD-CARD interaction, leading to downstream activation of NF-κB.
This antibody recognizes protein from transgenic and transfected cells.
Applications reported include immunoblotting (WB), and it has been validated on transfected cell lines and NOD2-transgenic mouse cells.
Target Information
NOD2 is a member of the apoptosis-regulating protein family that includes Apaf-1 and NOD1, containing:
- Two N-terminal CARDs
- A nucleotide binding domain (NBD)
- Multiple C-terminal leucine-rich repeats (LRRs)
NOD2 is primarily expressed in monocytes, whereas NOD1 is expressed in multiple tissues.
It regulates NF-κB signaling, acts as an intracellular receptor for bacterial lipopolysaccharides, and is associated with inflammatory bowel disease (IBD) and Crohn’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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