Thermo Fisher Scientific PIK3R6 Polyclonal Antibody
PIK3R6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며, 인간 시료에 반응. 액상 형태로 1 mg/mL 농도, PBS 및 50% glycerol 버퍼에 보관. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PIK3R6 (Accession Q5UE93), corresponding to amino acid residues G614–F664 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853345 |
Product Specific Information
Antibody detects endogenous levels of total PIK3R6.
Target Information
p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84 or HsT41028, is a 754 amino acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex.
It is expressed in heart, dendritic cells, macrophages, and neutrophils. p87PIKAP drives PI 3-kinase p110 activation, interacts with PDE3B, and forms a scaffolding interaction.
The gene encoding p87PIKAP maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Two key tumor suppressor genes, p53 and BRCA1, are located on chromosome 17. p53 maintains genetic integrity through DNA repair and apoptosis regulation, while BRCA1 is involved in DNA repair and associated with predisposition to breast, ovarian, colon, prostate, and fallopian tube cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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