Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/8407R)
에스트로겐 의존성 마커로 사용되는 인간 ERα에 특이적인 재조합 토끼 단클론 항체. IHC(P) 및 IHC(PFA) 실험에 적합하며, CHO 세포 발현 시스템 기반으로 생산됨. Protein A/G 정제, PBS 완충액에 0.05% BSA 및 sodium azide 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ESR1/8407R |
| Immunogen | Recombinant fragment (around aa495–595) of human ER alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This interaction allows ER to regulate gene transcription positively or negatively through coactivator or corepressor recruitment.
Two main forms exist: ERα (ESR1) and ERβ (ESR2), encoded by separate genes. Alternative RNA splicing generates at least four ERα isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed and are crucial for sexual development, reproductive function, and bone health. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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