Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/8206R)
인간 Estrogen Receptor α(ESR1)을 표적하는 재조합 토끼 단클론 항체로, ELISA 등 연구용 분석에 적합합니다. HEK293 세포에서 발현되었으며, Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 진단용 사용 불가.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/8206R)
Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/8206R)
Applications
- ELISA
Tested Dilution
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ESR1/8206R |
| Immunogen | Recombinant fragment (around aa495–595) of human ER alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
When bound to EREs, ER can positively or negatively regulate gene transcription through recruitment of coactivator or corepressor proteins.
There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively).
Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known to exist:
- Isoform 1 (66 kDa)
- Isoform 2 (53 kDa)
- Isoform 3 (47 kDa)
- Isoform 4 (35 kDa)
Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play roles in other tissues such as bone and are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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