Thermo Fisher Scientific KPNA6 Polyclonal Antibody
KPNA6 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC(P)에서 사용 가능. 인간에 반응하며, 서열 상 유사성으로 다른 종에서도 반응 예측. 액상 형태로 제공되며 -20°C 보관. 연구용 전용.
- 카탈로그번호
- PA518935
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (STTGESVITREMVE) corresponding to the internal amino acids of KPNA6 (aa 74–88) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10981761 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Karyopherin is a cytosolic and heterodimeric protein complex composed of alpha and beta subunits. It mediates the transport of proteins containing nuclear localization signals to the nuclear pore complex (NPC) via an energy-dependent, Ran-mediated mechanism.
The alpha subunit and imported substrate accumulate in the nucleoplasm, while the beta subunit localizes at the NPC.
KPNA6, a member of the KPNA subfamily (including IPOA5 & IPOA6), plays a crucial role in nuclear import. Down-regulation of KPNA6 in HeLa cells inhibits cell proliferation, likely due to impaired nuclear import of essential growth factors. KPNA6 also interacts with the HIV-1 Rev protein, facilitating its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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