Thermo Fisher Scientific GPR125 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways.
G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and respond to various signaling molecules such as hormones and neurotransmitters.

GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily.
It is considered a novel orphan adhesion-type G-protein-coupled receptor with five leucine rich repeats (LRR), an immunoglobulin (Ig) domain, and a GPS domain.
GPR125 may play a functional role in choroidal and hippocampal response to brain injury and may serve as a marker for spermatogonial stem cells.
Four isoforms of GPR125 exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.