Thermo Fisher Scientific WWOX Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• View 1 publication

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing.
This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD).
The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate.
This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism.
The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein.
In addition, there is evidence that this gene behaves as a suppressor of tumor growth.
Alternative splicing of this gene generates transcript variants that encode different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.