Thermo Fisher Scientific WWOX Polyclonal Antibody
WWOX 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합합니다. 인간, 마우스, 원숭이, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 합성 펩타이드 면역원 기반, 액상 형태이며 -20°C에서 보관합니다.
- 카탈로그번호
- PA517237
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Thr103 of WWOX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980309 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing.
This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD).
The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate.
This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism.
The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein.
In addition, there is evidence that this gene behaves as a suppressor of tumor growth.
Alternative splicing of this gene generates transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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