Thermo Fisher Scientific GNAT3 Polyclonal Antibody
GNAT3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Mouse 및 Rat 시료에 반응. Western blot 및 IHC에 적합하며, bitter/sweet/umami taste transduction 연구에 활용 가능. Lyophilized 형태로 안정적 저장 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of mouse GNAT3 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen shares 87% identity with the rat sequence.
- Specificity: GNAT3.
Target Information
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.
Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP, which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter.
GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.
Functions also as lumenal sugar sensors in the gut to control the expression of the Na⁺-glucose transporter SGLT1 in response to dietary sugar, as well as secretion of Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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