Thermo Fisher Scientific RIP3 Polyclonal Antibody
RIP3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 비결합형 액상 형태로 제공되며, 4°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 to 450 of Human Receptor Interacting Protein 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm and is colocalized in the mitochondrion, capable of nucleocytoplasmic shuttling dependent on nuclear localization and export signals. It is part of the TNF receptor-I signaling complex, can induce apoptosis, and weakly activates NF-kappaB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is required for its protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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