Thermo Fisher Scientific Resistin Polyclonal Antibody

Thermo Fisher Scientific Resistin Polyclonal Antibody

Applications

• ELISA (ELISA)

Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• PA1-75380 specifically detects Resistin.
• PA1-75380 has been successfully used in ELISA applications.
• The PA1-75380 immunogen is Recombinant Resistin.

Target Information

Adipose tissue is an energy reserve in animals and is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. While the function of resistin is not well understood, it appears to have key paracrine roles and a suggested role in type 2 diabetes.
Studies show that in obese, diabetic mice, serum resistin levels are increased, which antagonizes insulin. Additional studies demonstrate that resistin causes insulin resistance and glucose intolerance in mice.
Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Coactivators CBP and p300, with histone acetyltransferase (HAT) activity, acetylate histones at the resistin promoter, activating chromatin for resistin transcription. Numerous PPAR gamma and RXR ligands downregulate resistin expression in adipocytes.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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