Thermo Fisher Scientific UBASH3A Polyclonal Antibody
UBASH3A 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 자랑합니다. PBS 및 글리세롤 완충액에 보관되며 연구용으로만 사용 가능합니다.
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- PA575576
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카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 356–401 of Human UBASH3A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719304 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized to both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain. TULA is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes. It can form homodimers or homo-oligomers that interfere with degradation of receptor-type tyrosine kinases, promoting accumulation of activated receptors on the cell surface. TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, located on human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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