Thermo Fisher Scientific Importin 11/IPO11 Polyclonal Antibody
Human 및 Mouse 반응성을 가진 Rabbit Polyclonal Antibody로, Importin 11(IPO11)을 검출. Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태로 1 mg/mL 농도. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 925 to 975 of human Importin-11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
IPO11 functions as a nuclear transport receptor involved in nuclear protein import. It recognizes nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through nucleoporin binding. The complex is translocated through the pore via a Ran-dependent mechanism. Ran binding at the nucleoplasmic side facilitates dissociation of the importin/substrate complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. The asymmetric distribution of Ran-GTP and Ran-GDP between cytoplasm and nucleus confers directionality of nuclear import. IPO11 mediates nuclear import of UBE2E3 and RPL12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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