Thermo Fisher Scientific Importin 11/IPO11 Polyclonal Antibody
Human Importin 11(IPO11)에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 핵 단백질 수입 연구용으로 적합하며, 4°C에서 보관. 연구용 한정 제품.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 825 to 875 of human Importin-11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) via nucleoporin binding. The complex is translocated through the pore by an energy-requiring, Ran-dependent mechanism. Ran binding at the nucleoplasmic side causes dissociation of the complex and re-export of importin to the cytoplasm, where GTP hydrolysis releases Ran. This asymmetric Ran distribution confers directionality of nuclear import. IPO11 mediates nuclear import of UBE2E3 and RPL12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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