Thermo Fisher Scientific GABBR1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GABBR1 subunit. Validated for Western blot applications. Recognizes residues 33–54 of GABABR1. Supplied in liquid form and stored at 4°C or -20°C. For research use only.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 33–54 (PHLPRPHPRVPPHPSSERRAVY) of the GABABR1 subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1957665 |
Product Specific Information
PA1-32248 detects GABBR1 from human samples.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis.
Plays a critical role in fine-tuning inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance underlying late inhibitory postsynaptic potentials.
Also implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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