Thermo Fisher Scientific ACD Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 83%; Dog: 85%; Guinea Pig: 85%; Horse: 85%; Human: 85%; Mouse: 100%; Rat: 93%

Target Information

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway.
The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase, which converts orotic acid to orotidine-5'-monophosphate.
The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase, which converts orotidine-5'-monophosphate to uridine monophosphate.
Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.