Thermo Fisher Scientific ESX1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 2.5 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Mouse: 100%

Target Information

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis, containing two functional domains: the homeodomain and the proline-rich domain.
During embryogenesis, ESX1 is expressed in extraembryonic tissues including the endoderm of the visceral yolk sac, the ectoderm of the chorion, and the labyrinthine trophoblast of the chorioallantoic placenta.
ESX1 can act as a transcriptional repressor to the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorigenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-68761_ESX1_Q8N693-1_Rabbit.svg, PA5-68761_ESX1_Q8N693-1_Rabbit_PDP.jpeg)