Thermo Fisher Scientific Pannexin 1 Polyclonal Antibody
Pannexin 1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ELISA, IP에 적합. 고순도 친화 크로마토그래피 정제 제품으로 안정한 액상 형태. 인간 시료에 반응하며, 연구용으로 ER Ca2+ 항상성 및 세포 간 ATP 전달 연구에 활용 가능.
- 카탈로그번호
- PANX1-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region from human Pannexin 1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins that are highly conserved among invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels.
Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is more distantly related. PANX1 forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. It may function as a Ca²⁺ leak channel to regulate ER Ca²⁺ homeostasis and influence neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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