Thermo Fisher Scientific Human APC2 Synthetic Peptide
인간 APC2 단백질의 중심부 18개 아미노산으로 구성된 합성 펩타이드입니다. 항체 PA5-20944의 블로킹 펩타이드로 사용 가능합니다. 세포주기 조절 및 APC/C 복합체 연구에 적합합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human APC2.
PEP-1058 can be used as a blocking peptide with polyclonal antibody PA5-20944.
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis.
APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence.
The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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