Thermo Fisher Scientific Torc2 Polyclonal Antibody
Human TORC2(CRTC2) 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 최적화됨. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Gly328 of human TORC2 (CRTC2) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 23.7 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981768 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2, and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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