Thermo Fisher Scientific ATGL Polyclonal Antibody
ATGL 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot, ICC/IF, IP 등 다양한 응용에 적합합니다. 인간 및 생쥐 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 연구용으로 사용됩니다.
- 카탈로그번호
- PA517436
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- pk
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Thermo Fisher Scientific ATGL Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:400–1:1,600 | View 1 publication |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a sequence around Pro186 of human ATGL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 142 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982805 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Lipolytic enzymes are essential for mobilizing fatty acids from triglyceride stores in adipose tissue. Dysfunctional lipolysis affects energy homeostasis and may contribute to obesity and insulin resistance. Hormone-sensitive lipase (HSL) was previously considered the only enzyme hydrolyzing triglycerides in mammalian adipose tissue, but adipose triglyceride lipase (ATGL) is now known to catalyze the initial step in triglyceride hydrolysis.
ATGL is highly expressed in adipose tissues of mice and humans, showing high substrate specificity for triacylglycerol and association with lipid droplets. Inhibition of ATGL decreases total adipose acyl-hydrolase activity, indicating that ATGL and HSL coordinate triglyceride catabolism in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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