Thermo Fisher Scientific Phospho-TGFBR1 (Ser165) Polyclonal Antibody
TGFBR1의 Ser165 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 6 publications |
| ELISA | 1:5,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TGFβRI around the phosphorylation site of S165 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607325 |
Product Specific Information
This antibody is predicted to react with human and rat based on sequence homology.
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which includes ACVRs and BMPRs. Upon binding TGF-β, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation, leading to downstream phosphorylation of SMADs. TGFBR1 forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the signal from the cell surface to the cytoplasm. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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