Thermo Fisher Scientific PER1 protein Polyclonal Antibody
PER1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도 Protein A 정제 및 안정한 보존용액으로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PER1 protein (amino acids 751–850) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Circadian rhythmicity is a fundamental property across diverse organisms including animals, plants, and fungi. Regulation of endogenous biological clocks occurs via a protein-mediated autoregulatory feedback loop. In mammals, members of the basic helix-loop-helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family are key regulators of circadian oscillations. CLOCK-induced genes are transactivated through E-box enhancers (CACGTG) located upstream of target genes. CLOCK-ARNT3 heterodimers bind to these regulatory elements to stimulate transcription. The PER protein, together with the mammalian timeless gene (TIM) product, negatively regulates its own transcription by inhibiting the CLOCK-BMAL1 transactivation complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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