Thermo Fisher Scientific LMAN1 Polyclonal Antibody

Thermo Fisher Scientific LMAN1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  PGKEPPTPDK EISEKEKEKY QEEFEHFQQE LDKKKEEFQK GHPDLQGQPA EEIFESVGDR ELRQVFEGQN RIHLEIKQLN RQLDMILDEQ RRYVSSLTEE ISKRGAGMPG QHGQITQQEL DTVVKTQHEI LRQVNEMKNS MSETVRLVSG MQHPGSAGGV YETTQHFIDI KEHLHIVKRD IDNLVQRNMP SNEKPKCPEL PPFPSCLSTV H
• Positive Samples: BT-474, LO2, U-251MG
• Cellular Location: Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass membrane protein, Single-pass type I membrane protein

Target Information

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, recycling between the two compartments. It is a mannose-specific lectin and a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in this gene are associated with a coagulation defect, identified as the disease gene leading to combined factor V–factor VIII deficiency, a rare autosomal recessive disorder with diminished coagulation factors V and VIII.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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