Thermo Fisher Scientific ADAM10 Polyclonal Antibody
ADAM10 단백질을 타깃으로 하는 Thermo Fisher의 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA에 사용 가능. Human과 Mouse 시료에 반응하며, 세포막 및 내막계 단백질 검출에 적합. -20°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Category | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 218–433 of human ADAM10 (NP_0011011) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804489 |
Product Specific Information
- Positive Samples: HT-1080, Raji, Jurkat, Mouse kidney, Mouse brain
- Cellular Location: Cell membrane, Endomembrane system, Single-pass type I membrane protein
Immunogen sequence:
EKNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN ISFMVKRIRI NTTADEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM YARATSGDKL NNNKFS
Target Information
Proinflammatory cytokine TNF-α contributes to inflammatory responses and programmed cell death. Notch receptor and its ligand are involved in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-α, Notch, and its ligand Delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors. ADAM10, a metalloprotease-disintegrin in the ADAM family, cleaves TNF-α, Notch, and Delta. The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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