Thermo Fisher Scientific BST-2 Polyclonal Antibody
BST-2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, Flow Cytometry 등 다양한 응용에 사용 가능. Human, Mouse, Rat 등 반응. Protein A로 정제된 액상 형태이며 1 mg/mL 농도. HIV 연구 및 면역학 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | – |
| Flow Cytometry (Flow) | Assay-Dependent | – |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 80–130 of human BST2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541005 |
Target Information
BST2 (also known as CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in the development and growth of B-cells. Surface expression of BST2 on fibroblast cell lines facilitates stromal cell-dependent growth of pre-B-cell lines.
BST2 is highly expressed during B-cell development (from pro-B precursors to plasma cells), as well as in T-cells, monocytes, NK cells, DCs, and myeloma cells. Studies show that BST2 inhibits retrovirus release from human cells, a process antagonized by the HIV-1 accessory protein Vpu.
Depletion of BST2 abolishes the viral requirement for Vpu, suggesting a potential therapeutic strategy for HIV/AIDS. BST2 dysfunction is also associated with stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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