Thermo Fisher Scientific SARS/SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Mouse Monoclonal Antibody (D005)

Applications

Western Blot (WB)

• Tested Dilution: 정보 없음
• View 1 publication

ELISA

• Tested Dilution: 1:5,000–1:10,000
• View 2 publications

Product Specifications

Product Specific Information

This product is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant SARS-CoV Spike RBD Protein. The antibody was produced using recombinant antibody technology.

Target Information

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold symptoms to severe respiratory distress and death.
The CoV Spike (S) protein is crucial for viral attachment, fusion, and entry, serving as a key target for antibody development, entry inhibitors, and vaccines.
The Spike protein receptor-binding domain (RBD, S-RBD) binds strongly to human and bat ACE2 receptors, with SARS-CoV-2 RBD showing higher binding affinity to ACE2 than SARS-CoV RBD.
The S1 subunit contains the RBD that specifically binds to ACE2 receptors on target cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.