Thermo Fisher Scientific SUPT5H Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan

Target Information

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.
DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A.
It acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at promoter-proximal sites, facilitating assembly of elongation-competent RNA polymerase II complexes.
DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II.
DSIF also positively regulates transcriptional elongation and is required for efficient activation by the HIV-1 Tat protein, suppressing premature transcript release from the HIV-1 LTR.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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