Thermo Fisher Scientific PGR Monoclonal Antibody (OTI5C12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events such as the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to alternative translation initiation sites. PR-B is the transcriptionally active form responsible for endometrial maintenance, pregnancy support, and ovulation inhibition.
PR-A differs from PR-B by a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, conformational changes allow dimerization and binding to progesterone response elements (PREs), activating transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.