Thermo Fisher Scientific PGR Monoclonal Antibody (OTI20A11), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events such as pregnancy establishment and maintenance. PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), due to alternative translation initiation sites.
PR-B is the transcriptionally active form responsible for activating genes involved in endometrial maintenance and ovulation inhibition. PR-A differs by a 165 amino acid deletion at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable receptor dimerization and binding to progesterone response elements (PRE), resulting in transcriptional activation.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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