Thermo Fisher Scientific EDA2R Monoclonal Antibody (5D7E3)

Applications and Tested Dilution

• ELISA (ELISA): 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human XEDAR/EDA2R.

Target Information

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently identified member of the tumor necrosis factor receptor family, highly expressed during embryonic development and binding to ectodysplasin-A2 (EDA-A2). Two main isoforms, XEDAR-s and XEDAR-L, differ by a 21-amino acid region in the cytoplasmic domain. Neither isoform contains a death domain, and both signal mainly through TRAF3 and TRAF6 to activate NF-κB and JNK pathways.
Cells expressing XEDAR and treated with EDA-A2 form a complex with FADD, caspase-8, and caspase-10, leading to activation of caspase-8 and caspase-3, and ultimately apoptosis. EDA-A2-induced apoptosis depends on caspase-9 activation, as inhibitors of caspase-8 block apoptosis following EDA-A2 treatment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.