Thermo Fisher Scientific Phospho-Btk (Ser180) Monoclonal Antibody (3i5 (3D3))
인간 BTK 단백질의 Ser180 인산화 부위를 인식하는 마우스 단클론 항체. Western blot 및 ELISA에 적합하며, 비결합형 액상 형태로 제공됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
ELISA
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3i5 (3D3) |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding Ser180 of human Btk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | 0.01M HEPES buffered saline/ascites, pH 7.5, with 0.1mg/mL BSA, 50% glycerol, 150mM NaCl |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2067681 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are critical for innate and adaptive immunity.
Additionally, BTK interacts with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its role in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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