Thermo Fisher Scientific TLR2 Monoclonal Antibody (11G7)
인간 TLR2를 인식하는 Mouse IgG1 단클론 항체로, ELISA, FACS, IP에 사용 가능. 비접합 형태로 제공되며, 다양한 형광 및 비오틴 포맷 지원. Protein G 정제, PBS 버퍼 및 sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific TLR2 Monoclonal Antibody (11G7)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1.0 µg/1x10^6 cells |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11G7 |
| Immunogen | Human TLR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539111 |
Additional Formats
- Biotin conjugate: MA5-17722
- FITC conjugate: MA5-17723
- PE conjugate: MA5-17724
- Custom conjugation available upon request
Product Specific Information
MA5-17721 targets CD282/TLR2/Toll-like Receptor 2 in ELISA, FACS, and IP applications and shows reactivity with human samples.
The immunogen used is human TLR2.
Target Information
TLR2 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize various bacterial and mycoplasma lipoproteins.
It is highly expressed in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast via NF-kappaB activation.
Expression levels vary among cell types: CD14+ monocytes show the highest expression, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.
TLR2 expression is modulated by immune response modifiers — upregulated by LPS, GM-CSF, IL-1, and IL-10; downregulated by IL-4, IFN-γ, and TNF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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