Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61), FITC
인간 CD163 단백질을 인식하는 마우스 단클론 항체로, FITC로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. PBS/BSA 완충액에 보존되며 단기 4°C, 장기 -20°C에서 보관합니다. 단백질 G로 정제된 고품질 연구용 항체입니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GHI/61 |
| Immunogen | Mouse monoclonal antibodies raised against human CD163 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539109 |
Additional Formats
- Unconjugated (MA5-17716)
- APC (MA5-17717)
- Biotin (MA5-17718)
- PE (MA5-17720)
- Custom conjugation available upon request
Product Specific Information
MA5-17719 targets CD163/M130 in FACS applications and shows reactivity with human samples.
The immunogen is mouse monoclonal antibodies raised against human CD163.
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It functions as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage and aiding in iron recycling through endocytosis and heme breakdown.
CD163 is expressed exclusively on human monocytes and macrophages, particularly in the late phase of inflammation. It is found on all circulating monocytes and most tissue macrophages, except those in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells, and Langerhans cells.
Expression is higher on CD16⁺ monocytes and is upregulated by IL-10, IL-6, and dexamethasone. LPS and PMA induce shedding of CD163 from the cell surface. CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, showing higher affinity for HP1F-type complexes. It also triggers intracellular signaling involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL-6 and CSF1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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